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The substitution lowers the affinity of MTHFR and its cofactor, which promotes the thermolability and diminishes the enzyme activity

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That same month, the journal Science declared glucagon-like peptide-1 (GLP-1) weight loss drugs its Breakthrough of the Year, beating out commendable contenders such as new malaria and Alzheimers treatments, innovative climate change research on natural carbon pumps and artificial intelligence (AI) in improving weather forecasting

Novo Nordisk declined to comment on that lobbying activity